Interested in AAFP membership? Learn more. Wenzel V, et al. A comparison of vasopressin and epinephrine for out-of-hospital cardiopulmonary resuscitation. N Engl J Med.
January 8, ; An accompanying editorial 1 by McIntyre speculates on the reasons that the survival advantage of vasopressin may be limited to patients with asystole. Epinephrine and other catecholamines appear to be less effective vasopressors in the hypoxic, acidotic cardiac environment of asystole.
He notes that the increased myocardial oxygen consumption occurring with epinephrine may have harmful effects in patients with asystolic cardiac arrest.
Mcintyre KM. Vasopressin in asystolic cardiac arrest [Editorial]. Vasopressin and Epinephrine Versus Epinephrine Alone in Cardiac Arrest The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U. Federal Government. Read our disclaimer for details. Last Update Posted : October 17, Study Description.
Recent studies have suggested that arginine-vasopressin could be more effective in the treatment of cardiac arrests.
The last published study did not outline obvious improvements in the prognosis of all cardiac arrests but pointed out a possible increased survival rate when arginine-vasopressin is associated with epinephrine. The aim of this study is to compare the efficacy of two successive injections of epinephrine 1 mg with two successive injections of epinephrine associated with arginine-vasopressin 40 UI in out-of-hospital cardiac arrests occurring in adult patients.
The primary endpoint is the survival rate at hospital admission. The inclusion period lasts 18 months and patients are planned to be enrolled. FDA Resources. Arms and Interventions. Other Names: Arginine vasopressin argipressin antidiuretic hormone.
Outcome Measures. Neurological status is assessed by the Glasgow-Pittsburgh outcome categories, to evaluate quality of life after successful resuscitation. Return of spontaneous circulation is defined as the presence of any palpable pulse detected by manual palpation of a major artery.
Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials. More Information. Publications automatically indexed to this study by ClinicalTrials.
A randomised, double-blind, multi-centre trial comparing vasopressin and adrenaline in patients with cardiac arrest presenting to or in the Emergency Department. Epub Feb Pharmacol Ther. Google Scholar. Lab Anim. Section 4. Adult advanced life support. American Heart Association in collaboration with International Liaison Committee on Resuscitation: Guidelines for cardiopulmonary resuscitation and emergency cardiovascular care: international consensus on science.
Part 6. Advanced cardiovascular life support: section 6. Pharmacology II: agents to optimize cardiac output and blood pressure. N Engl J Med. Zhong J, Dorian P: Epinephrine and vasopressin during cardiopulmonary resuscitation. Regul Pept. Ann Intern Med. Prehosp Emerg Care. Br J Pharmacol. Barlow M: Vasopressin. Emerg Med Fremantle. Aung K, Htay T: Vasopressin for cardiac arrest. A systematic review and meta-analysis. Arch Intern Med. A meta-analysis. Curr Opin Crit Care.
Am J Emerg Med. Anesth Analg. Frenneaux M: Cardiopulmonary resuscitation-some physiological consideration. Download references. This project is co-financed with Op. You can also search for this author in PubMed Google Scholar. Correspondence to Theodoros Xanthos. KS participated in the study design and drafted the manuscript. TX participated in the study design and revised the manuscript critically for important intellectual content. GR participated in performing the surgical preparation of this model and has made substantial contributions to the design of this model.
VK participated in the experimentation and collected the final data. DPa was responsible for animal welfare and performed autopsies on the animals. IS participated in the experimentation and collected the final data. Reprints and Permissions. Stroumpoulis, K. Vasopressin and epinephrine in the treatment of cardiac arrest: an experimental study. Crit Care 12, R40 Download citation. Received : 22 October Revised : 04 January Accepted : 14 March Published : 14 March Anyone you share the following link with will be able to read this content:.
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