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Each breast contains 15 to 20 lobes of glandular tissue, arranged like the petals of a daisy. The lobes are further divided into smaller lobules that produce milk for breastfeeding. Small tubes ducts conduct the milk to a reservoir that lies just beneath your nipple. Doctors know that inflammatory breast cancer begins when a breast cell develops changes in its DNA.
Most often the cell is located in one of the tubes ducts that carry breast milk to the nipple. But the cancer can also begin with a cell in the glandular tissue lobules where breast milk is produced. A cell's DNA contains the instructions that tell a cell what to do. The changes to the DNA tell the breast cell to grow and divide rapidly.
The accumulating abnormal cells infiltrate and clog the lymphatic vessels in the skin of the breast. The blockage in the lymphatic vessels causes red, swollen and dimpled skin — a classic sign of inflammatory breast cancer. Inflammatory breast cancer usually starts with the reddening and swelling of the breast instead of a distinct lump.
IBC tends to grow and spread quickly, with symptoms worsening within days or even hours. Although inflammatory breast cancer is a serious diagnosis, keep in mind that treatments today are better at controlling the disease than they used to be.
The average age at diagnosis for inflammatory breast cancer in the United States is 57 for white women and 52 for Black women. These ages are about 5 years younger than the average ages at diagnosis for other forms of breast cancer. A U-M Rogel Cancer study provides an updated, more comprehensive look at trends for this rare, aggressive form of breast cancer over the last four decades. Women with inflammatory breast cancer — a rare, highly aggressive form of the disease — are living about twice as long after diagnosis than their counterparts in the mid-to-late s, according to a new University of Michigan Rogel Cancer Center study.
The researchers found that from , patients diagnosed with inflammatory breast cancer, also known as IBC, survived for an average of about 50 months, compared to months for patients diagnosed from But despite overall improvements in survival, the analysis showed an ongoing disparity between white patients and Black patients.
And while the gap has narrowed slightly over time, white patients today still tend to live about two years longer than their Black peers, the group found. A pathologist analyzes the tissue sample in a lab to check for the presence of cancer cells and other indications of IBC.
If cancer is detected, the pathologist will also determine the hormone receptor and HER2 status of the cancer cells. Sometimes biopsy of the skin of the breast is also necessary. How is inflammatory breast cancer treated? Chemotherapy uses drugs to kill cancer cells. In patients whose tumors respond well to neoadjuvant chemotherapy, surgery to remove cancerous breast tissue is usually the next stage of treatment.
This usually involves a mastectomy, which is the surgical removal of the entire breast, typically along with the lymph nodes under the adjacent armpit. Once treatment is complete, patients may wish to undergo breast reconstruction surgery. Radiation therapy. This treatment kills cancer cells by exposing them to radiation.
It is typically used following surgery to eradicate any remaining cancer cells. Hormone therapy. Breast cancer cells may be hormone receptor-positive HR-positive. When these hormones bind to the receptors, they help the cancer cells grow. Hormone therapy is usually used after surgery. Targeted therapies.
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